抗ST2单克隆抗体抑制广州管圆线虫感染小鼠的嗜酸性粒细胞浸润。
Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice.
作者信息
Chuang Chih-Cheng, Chen Chi-Wu, Huang Yu-Tzu, Du Wen-Yuan
机构信息
School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan; Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Department of Cosmetic Science, Vanung University, Zhongli City, Taoyuan, Taiwan.
出版信息
J Microbiol Immunol Infect. 2016 Feb;49(1):91-6. doi: 10.1016/j.jmii.2014.01.009. Epub 2014 Mar 21.
BACKGROUND/PURPOSE: Interleukin-33 (IL-33) could play an important role in the pathogenesis of angiostrongylosis. However, the role of IL-33/ST2 pathway in this parasitic infection is uncertain.
METHODS
C57BL/six mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-ST2 monoclonal antibody (mAb; 50 μg) 3 days postinfection and subsequent booster shots of the same dose at 5-day intervals. Blood samples from each group were collected every week for assays.
RESULTS
The level of IL-5 significantly decreased in the mAb-treated group, and the infiltration of eosinophils in the meninges was also significantly reduced.
CONCLUSION
The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection.
背景/目的：白细胞介素-33（IL-33）可能在广州管圆线虫病的发病机制中起重要作用。然而，IL-33/ST2通路在这种寄生虫感染中的作用尚不确定。
方法
将35条广州管圆线虫幼虫分别感染C57BL/6小鼠。一组小鼠在感染后3天腹腔注射抗ST2单克隆抗体（mAb；50μg），并在5天间隔后进行相同剂量的加强注射。每周收集每组的血样进行检测。
结果
mAb治疗组中IL-5水平显著降低，脑膜中嗜酸性粒细胞浸润也显著减少。
结论
IL-33/ST2轴可能在广州管圆线虫病的发病机制中起关键作用，本研究结果可能有助于制定减少这种寄生虫感染所致神经损伤的策略。
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