源自 HIV-1 gp120 共受体结合域的肽形成淀粉样纤维并增强 HIV-1 感染。
Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection.
机构信息
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, USA.
Lindsley F. Kimball Research Institute, New York Blood Center, New York, USA; Key Laboratory of Medical Molecular Virology of the Ministries of Education & Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
出版信息
FEBS Lett. 2014 May 2;588(9):1515-22. doi: 10.1016/j.febslet.2014.03.016. Epub 2014 Mar 18.
Amyloid fibrils play important roles in HIV-1 infection. We found peptides derived from the HIV-1 gp120 co-receptor binding region, which are defined as enhancing peptides (EPs), could form amyloid fibrils and remarkably enhance HIV-1 infection. EPs bound to the virus and promoted the interaction between HIV-1 and target cells. The antiviral efficacy of antiretroviral drugs (ARVs) was substantially impaired in the presence of EPs. Epigallocatechin gallate (EGCG) could both inhibit the formation of fibrils composed of EPs and counteract the EP-mediated enhancement of HIV-1 infection. Our findings identify viral derived amyloid fibrils that hold potential for biochemical applications.
淀粉样纤维在 HIV-1 感染中发挥着重要作用。我们发现源自 HIV-1 gp120 共受体结合区的肽段可形成淀粉样纤维，显著增强 HIV-1 感染，这些肽段被定义为增强肽（EP）。EP 与病毒结合，并促进 HIV-1 与靶细胞的相互作用。在存在 EP 的情况下，抗逆转录病毒药物（ARV）的抗病毒疗效大大降低。表没食子儿茶素没食子酸酯（EGCG）既能抑制由 EP 组成的纤维的形成，又能拮抗 EP 介导的 HIV-1 感染增强作用。我们的研究结果确定了具有潜在生化应用价值的病毒衍生淀粉样纤维。
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