Babb Jessica A, Carini Lindsay M, Spears Stella L, Nephew Benjamin C
Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
Horm Behav. 2014 Apr;65(4):386-93. doi: 10.1016/j.yhbeh.2014.03.005. Epub 2014 Mar 19.
Social stressors such as depressed maternal care and family conflict are robust challenges which can have long-term physiological and behavioral effects on offspring and future generations. The current study investigates the transgenerational effects of an ethologically relevant chronic social stress on the behavior and endocrinology of juvenile and adult rats. Exposure to chronic social stress during lactation impairs maternal care in F0 lactating dams and the maternal care of the F1 offspring of those stressed F0 dams. The overall hypothesis was that the male and female F2 offspring of stressed F1 dams would display decreased social behavior as both juveniles and adults and that these behavioral effects would be accompanied by changes in plasma corticosterone, prolactin, and oxytocin. Both the female and male F2 offspring of dams exposed to chronic social stress displayed decreased social behavior as juveniles and adults, and these behavioral effects were accompanied by decreases in basal concentrations of corticosterone in both sexes, as well as elevated juvenile oxytocin and decreased adult prolactin in the female offspring. The data support the conclusion that social stress has transgenerational effects on the social behavior of the female and male offspring which are mediated by changes in the hypothalamic-pituitary-adrenal axis and hypothalamic-pituitary-gonadal axis. Social stress models are valuable resources in the study of the transgenerational effects of stress on the behavioral endocrinology of disorders such as depression, anxiety, autism, and other disorders involving disrupted social behavior.
诸如母性关怀缺失和家庭冲突等社会应激源是强大的挑战，会对后代及子孙后代产生长期的生理和行为影响。本研究调查了一种与行为学相关的慢性社会应激对幼年和成年大鼠行为及内分泌学的跨代影响。哺乳期暴露于慢性社会应激会损害F0代哺乳期母鼠的母性关怀，以及那些受应激的F0代母鼠的F1代后代的母性关怀。总体假设是，受应激的F1代母鼠的F2代雌雄后代在幼年和成年时都会表现出社交行为减少，并且这些行为影响会伴随着血浆皮质酮、催乳素和催产素的变化。暴露于慢性社会应激的母鼠的F2代雌雄后代在幼年和成年时均表现出社交行为减少，并且这些行为影响伴随着两性基础皮质酮浓度降低，以及雌性后代幼年催产素升高和成年催乳素降低。数据支持以下结论：社会应激对雌雄后代的社交行为具有跨代影响，这种影响由下丘脑-垂体-肾上腺轴和下丘脑-垂体-性腺轴的变化介导。社会应激模型是研究应激对抑郁症、焦虑症、自闭症和其他涉及社交行为紊乱的疾病的行为内分泌学的跨代影响的宝贵资源。
