Funaki Yukiha, Hiranuma Maya, Shibata Mai, Kokai Satoshi, Ono Takashi
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Arch Oral Biol. 2014 May;59(5):530-8. doi: 10.1016/j.archoralbio.2014.02.013. Epub 2014 Mar 2.
Nasal obstruction during growth changes craniofacial morphology and function. However, the etiological mechanisms of these changes are unknown. The aim of the present study was to investigate the effects of nasal obstruction during growth on the maturation of the jaw-opening reflex (JOR) using an electrophysiological technique. We focused on the oral sensory receptors that regulate the activities and reflexes of the orofacial muscles.
Sixty 6-day-old male Wistar rats were randomly divided into control and experimental groups (n = 30 each). The experimental group underwent unilateral nasal obstruction at 8 days of age. The JOR was evoked by bilateral, low-intensity electrical stimulation of the inferior alveolar nerve. The electromyographic responses were recorded bilaterally from the digastric muscles at 5, 7, and 9 weeks of age.
The latency of the JOR was significantly longer and the peak-to-peak amplitude was significantly smaller in the experimental group than in the control group at each age, while the duration was not significantly different. Intragroup comparison of the latency, peak-to-peak amplitude, and duration at 5, 7, and 9 weeks of age revealed no significant differences in either the control or experimental groups.
Unilateral nasal obstruction during growth may have significant effects on maturation of craniofacial function.
生长过程中的鼻塞会改变颅面形态和功能。然而，这些变化的病因机制尚不清楚。本研究的目的是使用电生理技术研究生长过程中鼻塞对张口反射（JOR）成熟的影响。我们重点关注调节口面部肌肉活动和反射的口腔感觉受体。
将60只6日龄雄性Wistar大鼠随机分为对照组和实验组（每组n = 30）。实验组在8日龄时进行单侧鼻塞。通过双侧低强度电刺激下牙槽神经诱发JOR。在5、7和9周龄时双侧记录二腹肌的肌电图反应。
在每个年龄，实验组JOR的潜伏期显著延长，峰峰值幅度显著小于对照组，而持续时间无显著差异。对5、7和9周龄时的潜伏期、峰峰值幅度和持续时间进行组内比较，发现对照组和实验组均无显著差异。
生长过程中的单侧鼻塞可能对颅面功能的成熟有显著影响。
