Amor Antonio J, Canivell Silvia, Oriola Josep, Ricart Maria J, de Hollanda Ana M, Bosch-Comas Anna, Esmatjes Enric
Nefrologia. 2014;34(2):212-5. doi: 10.3265/Nefrologia.pre2014.Feb.12034.
Few reports have studied the possible association between the haptoglobin (Hp) genotype and the risk of diabetic nephropathy (DN) in type 1 diabetes (T1D), with conflicting results to date.
To study whether the 2-2 Hp genotype is associated with an increased risk of overt DN in a Spanish population with T1D.
We performed a case-control study in a Spanish population.
T1D patients with end-stage renal disease (stage 5 of NKF-KDOQI), awaiting reno-pancreatic transplantation or having already been transplanted (reno-pancreatic or renal alone).
T1D patients, matched for sex and time of diabetes evolution, with preserved renal function and normal urinary albumin excretion. Hp genotyping was done using polymerase chain reaction and electrophoresis.
We included 57 cases and 57 controls in the study. There were no statistically significant differences in gender (70% vs. 61% males, p=1.0) or the duration of diabetes (23.0 ± 6.7 vs. 20.8 ± 9.3 years; p=0.1), although the age of onset of diabetes was lower in the cases (14.1 ± 6.8 vs. 17.7 ± 10.1 years, p=0.03). The frequency of genotypes 1-1, 1-2 and 2-2 was 19.3%, 42.1% and 38.6% in cases and 17.5%, 49.1% and 33.4% in controls, respectively, with no statistically significant differences between groups (p=0.8). Conditional logistic regression analysis showed no significant association between genotype 2-2 of Hp and the development of DN (OR 1.14, CI 0.52-2.52).
In our sample of a Spanish population with T1D, no association was found between the Hp genotype and risk of overt DN.
很少有报告研究1型糖尿病（T1D）患者中触珠蛋白（Hp）基因型与糖尿病肾病（DN）风险之间的可能关联，迄今为止结果相互矛盾。
研究在西班牙T1D人群中，2-2 Hp基因型是否与显性DN风险增加相关。
我们在西班牙人群中进行了一项病例对照研究。
患有终末期肾病（NKF-KDOQI 5期）、等待肾胰联合移植或已接受移植（肾胰联合移植或单纯肾移植）的T1D患者。
按性别和糖尿病病程匹配的T1D患者，肾功能正常且尿白蛋白排泄正常。使用聚合酶链反应和电泳进行Hp基因分型。
本研究纳入了57例病例和57例对照。性别（男性分别为70%和61%，p = 1.0）或糖尿病病程（23.0±6.7年和20.8±9.3年；p = 0.1）无统计学显著差异，不过病例组糖尿病发病年龄较低（14.1±6.8岁和17.7±10.1岁，p = 0.03）。病例组中1-1、1-2和2-2基因型的频率分别为19.3%、42.1%和38.6%，对照组中分别为17.5%、49.1%和33.4%，两组间无统计学显著差异（p = 0.8）。条件逻辑回归分析显示，Hp的2-2基因型与DN发生之间无显著关联（比值比1.14，95%置信区间0.52 - 2.52）。
在我们的西班牙T1D人群样本中，未发现Hp基因型与显性DN风险之间存在关联。
