Xing Pengyao, Chu Xiaoxiao, Ma Mingfang, Li Shangyang, Hao Aiyou
School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
Phys Chem Chem Phys. 2014 May 14;16(18):8346-59. doi: 10.1039/c4cp00367e.
Through a good/poor solvent strategy, native folic acid (FA) which behaves as a super-gelator in DMSO-water system can be successfully employed to construct supramolecular gels. The system exhibited morphological evolution with the increase of FA concentration; various phases such as vesicles, fiber/vesicles, fiber/nanoparticles, nanoparticles were probed. In the self-assembly process, l-glutamic acid moiety induced the formation of helical 1-dimensional (1-D) fibers which further self-assembled into a gel. Stimuli like heat, stress, pH and light which affect the molecular structure of FA or solubility in the mixed solvents had a pronounced influence on the properties of the gels, such as mechanical properties or bulk phases. A time-dependent oscillatory stress scan indicated that the supramolecular gel had a self-healing property. Without tedious modification routes and addition of alkali metal ions, native FA which served as an efficient building block and super-gelator to build up multi-responsive and self-recovery material was investigated for the first time.
通过良/不良溶剂策略，在二甲基亚砜-水体系中表现为超级凝胶剂的天然叶酸（FA）能够成功用于构建超分子凝胶。随着FA浓度的增加，该体系呈现出形态演变；探测到了各种相，如囊泡、纤维/囊泡、纤维/纳米颗粒、纳米颗粒。在自组装过程中，L-谷氨酸部分诱导形成螺旋一维（1-D）纤维，这些纤维进一步自组装成凝胶。诸如热、应力、pH值和光等影响FA分子结构或在混合溶剂中溶解度的刺激因素对凝胶的性能，如机械性能或整体相，有显著影响。随时间变化的振荡应力扫描表明该超分子凝胶具有自愈性能。首次研究了无需繁琐修饰路线和添加碱金属离子的天然FA，它作为构建多响应和自恢复材料的有效构建单元和超级凝胶剂。
