单胺氧化酶B（MAOB）A644G多态性与帕金森病风险的关系：一项荟萃分析。
The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis.
作者信息
Liu Ying, Wang Zhiyun, Zhang Benshu
机构信息
Benshu Zhang, 153 Anshan Rd.,, Tianjin 30052, China, +86 022 23626407,
出版信息
Ann Saudi Med. 2014 Jan-Feb;34(1):12-7. doi: 10.5144/0256-4947.2014.12.
BACKGROUND AND OBJECTIVES
Many studies were conducted to assess the relationship between Monoamine oxidase B (MAOB) A644G polymorphism and susceptibility to Parkinson disease (PD). However, the results were inconsistent and inconclusive.
DESIGN AND SETTINGS
A meta-analysis was conducted from all published studies on the associations between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease.
METHODS
In this present study, the possible relationship between MAOB A644G polymorphism and PD risk was assessed by a meta-analysis. Eligible articles were identified for the period up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed-effects models.
RESULTS
Twenty case-control studies with a total of 2846 cases and 3508 controls were eligible. In a recessive model, MAOB A644G polymorphism was associated with PD risk (OR=1.32, 95% CI 1.18-1.47, P < .001). Subgroup analyses by ethnicity and gender also found significant relationships between this polymorphism and PD risk.
CONCLUSION
This meta-analysis suggested that MAOB A644G polymorphism may be associated with PD development.
背景与目的
开展了许多研究以评估单胺氧化酶B（MAOB）A644G多态性与帕金森病（PD）易感性之间的关系。然而，结果并不一致且尚无定论。
设计与背景
对所有已发表的关于单胺氧化酶B（MAOB）A644G多态性与帕金森病关联的研究进行荟萃分析。
方法
在本研究中，通过荟萃分析评估MAOB A644G多态性与PD风险之间的可能关系。确定截至2013年3月期间符合条件的文章。采用固定效应模型适当得出合并比值比（OR）及95%置信区间（CI）。
结果
20项病例对照研究符合条件，共纳入2846例病例和3508例对照。在隐性模型中，MAOB A644G多态性与PD风险相关（OR = 1.32，95% CI 1.18 - 1.47，P <.001）。按种族和性别进行的亚组分析也发现该多态性与PD风险之间存在显著关系。
结论
该荟萃分析表明，MAOB A644G多态性可能与PD的发生有关。
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