Kakigi R
Department of Internal Medicine, Saga Medical School, Saga City, Japan.
Electroencephalogr Clin Neurophysiol. 1989 Mar-Apr;74(2):88-94. doi: 10.1016/0168-5597(89)90013-0.
Short-latency somatosensory evoked potentials (SEPs) following median nerve stimulation were recorded in 42 patients with Down's syndrome and in 42 age- and sex-matched normal subjects. There were no significant differences between the 2 groups in the absolute peak latencies of N9, N11 and N13 components. However, interpeak latencies, N9-N11, N11-N13 and N9-N13, were prolonged significantly in Down's syndrome. These findings suggest impaired impulse conduction in the proximal part of the brachial plexus, posterior roots and/or posterior column-medial lemniscal pathway. Interpeak latency N13-N20, representing conduction time from cervical cord to sensory cortex, was not significantly different between the 2 groups. Cortical potentials N20 and P25 in the parietal area and P20 and N25 in the frontal area were of significantly larger amplitude in Down's syndrome. P25 had double peaks in 16 of 42 normal subjects, but these were not apparent in any of the patients.
对42例唐氏综合征患者以及42名年龄和性别匹配的正常受试者进行了正中神经刺激后的短潜伏期体感诱发电位（SEP）记录。两组在N9、N11和N13成分的绝对峰潜伏期方面无显著差异。然而，唐氏综合征患者的峰间潜伏期，即N9-N11、N11-N13和N9-N13，显著延长。这些发现提示臂丛神经近端、后根和/或后索-内侧丘系通路的冲动传导受损。代表从颈髓到感觉皮层传导时间的峰间潜伏期N13-N20，两组之间无显著差异。唐氏综合征患者顶叶区域的皮层电位N20和P25以及额叶区域的P20和N25，其波幅显著更大。42名正常受试者中有16名P25有双峰，但在任何患者中均未出现这种情况。
