Yang Zhiwei, Zhang Yibin, Zhang Rui, Zhang Hongyu, Ma Jijiang, Chen Jinyu, Wang Jinfeng, Jiang Kaihui, Mu Danmei, Yu Yingjiao, Yang Haishan
Department of Radiology, China-Japan Union Hospital, Jilin University, 126 Xiantai St, Erdao District, 130033 Changchun, Jilin, China.
J Ultrasound Med. 2014 Apr;33(4):657-65. doi: 10.7863/ultra.33.4.657.
The purpose of this study was to explore the feasibility of high-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection in the treatment of uterine fibroids and to compare its therapeutic effects and potential side effects with those of simple high-intensity focused ultrasound treatment.
Forty patients with uterine fibroids from the Department of Ultrasonography in our hospital were randomly divided into 2 groups of the same size: group H, which only underwent high-intensity focused ultrasound treatment; and group H + A, which underwent sonographically guided intratumoral ethanol injection therapy first and then high-intensity focused ultrasound treatment the following day. The treatment times, treatment doses, pain scores, side effects, and therapeutic effect rates of the groups were then recorded and compared.
Both the treatment time and dose of group H + A were significantly less than those of group H, and the differences were statistically significant (P < .05). A lower pain score and fewer side effects were achieved in group H + A, also with statistically significant differences (P < .05). The therapeutic effect rate of group H + A was also higher than that of group H, and the difference was also statistically significant (P < .05).
In the treatment of uterine fibroids, high-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection requires less treatment time and a lower dose than simple high-intensity focused ultrasound treatment and significantly reduces the pain and side effects commonly experienced by patients. High-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection is a feasible, safe, and more effective way to treat patients with uterine fibroids.
本研究旨在探讨高强度聚焦超声联合超声引导下瘤内乙醇注射治疗子宫肌瘤的可行性，并将其治疗效果和潜在副作用与单纯高强度聚焦超声治疗进行比较。
将我院超声科的40例子宫肌瘤患者随机分为两组，每组20例：H组仅接受高强度聚焦超声治疗；H + A组先接受超声引导下瘤内乙醇注射治疗，次日再接受高强度聚焦超声治疗。然后记录并比较两组的治疗时间、治疗剂量、疼痛评分、副作用及治疗有效率。
H + A组的治疗时间和剂量均显著少于H组，差异有统计学意义（P <.05）。H + A组的疼痛评分更低，副作用更少，差异也有统计学意义（P <.05）。H + A组的治疗有效率也高于H组，差异同样有统计学意义（P <.05）。
在子宫肌瘤治疗中，高强度聚焦超声联合超声引导下瘤内乙醇注射比单纯高强度聚焦超声治疗所需的治疗时间更短、剂量更低，且能显著减轻患者常见的疼痛和副作用。高强度聚焦超声联合超声引导下瘤内乙醇注射是一种治疗子宫肌瘤患者的可行、安全且更有效的方法。
