Li Xianjiang, Chang Cuilan, Wang Xin, Bai Yu, Liu Huwei
Beijing National Laboratory for Molecular Sciences, The Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Electrophoresis. 2014 Oct;35(19):2733-43. doi: 10.1002/elps.201400079. Epub 2014 May 19.
Chiral separation is of great importance for drug development, pharmacology, and biology. Chiral metal-organic frameworks (MOFs) is a new class of porous solid materials with high surface area, large pore size, high chemical stability, uniformly structured cavities, and the availability of modification. The excellent properties of MOFs have attracted intense interest to explore their performance and mechanism in chiral separation. This review summarizes three synthetic strategies of chiral MOFs and their applications in enantioselective adsorption and chromatographic separation. All the experimental and molecular simulation results demonstrated that high enantioselectivity was strongly correlated with a close match between the size of the pore and chiral molecules.
手性分离在药物开发、药理学和生物学中具有重要意义。手性金属有机框架材料（MOFs）是一类新型的多孔固体材料，具有高比表面积、大孔径、高化学稳定性、结构均匀的空腔以及可修饰性。MOFs的优异性能引起了人们对探索其在手性分离中的性能和机理的浓厚兴趣。本文综述了手性MOFs的三种合成策略及其在对映体选择性吸附和色谱分离中的应用。所有实验和分子模拟结果表明，高对映体选择性与孔尺寸和手性分子之间的紧密匹配密切相关。
