Sendur Mehmet A N, Aksoy Sercan, Ozdemir Nuriye Y, Yaman Sebnem, Yazici Ozan, Bulent Akinci Muhammed, Uncu Dogan, Zengin Nurullah, Altundag Kadri
Ankara Numune Education and Research Hospital, Department of Medical Oncology, Ankara, Turkey.
J BUON. 2014 Jan-Mar;19(1):115-23.
Improved long-term survival of colorectal cancer patients (CRC) treated with surgery and/or chemotherapy ± radiotherapy (RT) has led to increased awareness of long-term side effects, including effecting sexual life, which can ultimately affect the quality of life in these patients. Because the absolute risk factors of erectile dysfunction (ED) have not been defined in CRC patients, the aim of this research was to identify the severity and the absolute risk factors of ED in male CRC survivors.
The medical records of 61 male survivors of CRC treated with surgery and/or chemotherapy ± RT were retrieved from the medical oncology outpatient clinics during routine follow-up visits in 2011-2012. Patients older than 55 years and those with ED history before diagnosis were excluded. International Index of Erectile Function (IIEF) questionnaire was filled in by the patients.
The patient mean age was 47.6±6.7 years (range 18-55) at the time of filling in the questionnaire. According to the International Index of Erectile Function (IIEF) score, 83.6% of the patients had some degree of ED. The risk factors of erectile dysfunction were advancing age (p=0.01), tumor location (p=0.01), type of surgery (p=0.02), presence of stoma (p=0.03)) and RT (p=0.005). Chemotherapy didn't impact ED (p=0.46). Also, there was no significant correlation between smoking status, hypertension, diabetes mellitus, cardiovascular disease, stage of the tumor and ED. Also hormonal disturbances such as serum FSH, LH and testesterone levels did not affect the presence of ED.
Overall, 83.6% of the male CRC survivors had some degree of ED according to the IIEF. The risk factors of ED were advancing age, tumor location, type of operation, presence of stoma and RT. Clinicians should be aware of these risk factors to offer their patients adequate treatment options and also come up with new treatment strategies necessary to reduce further ED in CRC survivors.
接受手术和/或化疗±放疗（RT）治疗的结直肠癌（CRC）患者长期生存率的提高，使得人们对包括影响性生活在内的长期副作用的认识有所增加，而这最终可能影响这些患者的生活质量。由于尚未明确CRC患者勃起功能障碍（ED）的绝对风险因素，本研究的目的是确定男性CRC幸存者中ED的严重程度和绝对风险因素。
2011年至2012年常规随访期间，从肿瘤内科门诊检索了61例接受手术和/或化疗±RT治疗的男性CRC幸存者的病历。排除年龄超过55岁以及诊断前有ED病史的患者。患者填写国际勃起功能指数（IIEF）问卷。
填写问卷时患者的平均年龄为47.6±6.7岁（范围18 - 55岁）。根据国际勃起功能指数（IIEF）评分，83.6%的患者有一定程度的ED。勃起功能障碍的风险因素包括年龄增长（p = 0.01）、肿瘤位置（p =
