Yan Jia, Li Yi-ran, Zhang Ying, Lu Yi, Jiang Hong
Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
J Child Neurol. 2014 Oct;29(10):1333-8. doi: 10.1177/0883073813517508. Epub 2014 Mar 20.
Animal experiments indicate that repeated exposure to ketamine adversely affects the developing brain. Whether it has the same effect on infants remains unclear. We recruited infants who were scheduled for 1 to 3 outpatient laser surgery treatments of benign facial growths with ketamine anesthesia. Patients were assigned to the Ket(1), Ket(2), or Ket(3) group, according to the number of treatments. The Bayley Scales of Infant Development-Second Edition (BSID-II) was used to assess neurodevelopmental outcomes before the first and after the last therapy. Levels of S-100β were also measured. Bayley Scales of Infant Development-Second Edition scores after the last procedure were lower than those before the first surgery in the Ket(3) group (P < .05). S-100β levels after the last procedure were significantly higher than those before the first surgery in all groups (P < .05). Our results suggest that 3 or more exposures to anesthetic ketamine have the potential to adversely affect neurodevelopment in infants.
动物实验表明，反复接触氯胺酮会对发育中的大脑产生不利影响。它对婴儿是否有同样的影响仍不清楚。我们招募了计划接受1至3次门诊激光手术治疗良性面部肿物并采用氯胺酮麻醉的婴儿。根据治疗次数将患者分为Ket(1)、Ket(2)或Ket(3)组。使用贝利婴儿发展量表第二版（BSID-II）在首次治疗前和最后一次治疗后评估神经发育结果。还测量了S-100β水平。Ket(3)组最后一次手术后的贝利婴儿发展量表第二版得分低于首次手术前（P <.05）。所有组最后一次手术后的S-100β水平均显著高于首次手术前（P <.05）。我们的结果表明，3次或更多次接触麻醉剂氯胺酮有可能对婴儿的神经发育产生不利影响。
