Joó József Gábor, Csatlós Eva, Brubel Réka, Bokor Attila, Karabélyos Csaba, Rigó János
Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
Biotest Hungaria Budapest.
Orv Hetil. 2014 Mar 30;155(13):492-9. doi: 10.1556/OH.2014.29860.
Epigenetic effects influence the function of genes regulating the main physiological mechanisms. Some of these environmental factors may reduce or inhibit the function of these genes. The environmental effects on gene function may result in a change of the DNA structure leading to non-heritable phenotype changes. Epigenetic factors play an important etiological role in the development of numerous diseases in obstetrics and gynecology. Uterine fibroids probably have a complex etiological background including epigenetic mechanisms. The multifactorial aetiology of endometriosis suggests key roles for immunological and hormonal factors in the development of the diseases. These mechanisms are influenced by epigenetic factors, which may serve as therapeutic targets in the future. The possible in utero origin of polycystic ovary syndrome determines the main directions of research concerning epigenetic factors in the etiological background, with the hope of eventual prevention and/or treatment in the preconceptional period as well as during pregnancy care.
表观遗传效应影响着调节主要生理机制的基因功能。其中一些环境因素可能会降低或抑制这些基因的功能。环境对基因功能的影响可能导致DNA结构的改变，从而引起非遗传性的表型变化。表观遗传因素在妇产科众多疾病的发生发展中起着重要的病因学作用。子宫肌瘤可能具有包括表观遗传机制在内的复杂病因背景。子宫内膜异位症的多因素病因表明免疫和激素因素在该疾病发生发展中起关键作用。这些机制受表观遗传因素影响，表观遗传因素未来可能成为治疗靶点。多囊卵巢综合征可能起源于子宫内，这决定了病因背景中有关表观遗传因素研究的主要方向，以期最终在孕前以及孕期护理中实现预防和/或治疗。
