Grunow G, Dikov M, Reimann H, Norden C, Jermolin G
Central Institute for Cardiovascular Research, Academy of Sciences of the GDR, Berlin.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):573-6.
The serum level of myoglobin (Mb) was determined in 11 male patients with chronic ischemic heart disease (angiographically studied) by the mean of an enzyme immunoassay (EIA). By a second EIA we could detect in all our patients autoantibodies (autoAB) to Mb. While the level of Mb in all cases was normal (less than 100 ng/ml) we found differences in the level of autoAB to Mb (normal value 90-100%). 7 patients with unstable Angina pectoris exhibited decreased levels of autoAB to Mb (65%). In 4 patients with stable Angina pectoris autoAB to Mb were 93%. The physiological role of the autoAB to Mb remains still unclear. The simultaneous determination of Mb and the autoAB to Mb may be helpful in differential diagnosis of stable and unstable Angina pectoris.
采用酶免疫测定法（EIA）测定了11例经血管造影研究的慢性缺血性心脏病男性患者的血清肌红蛋白（Mb）水平。通过第二次EIA，我们在所有患者中检测到了针对Mb的自身抗体（autoAB）。虽然所有病例中Mb水平均正常（低于100 ng/ml），但我们发现针对Mb的autoAB水平存在差异（正常值为90 - 100%）。7例不稳定型心绞痛患者针对Mb的autoAB水平降低（65%）。4例稳定型心绞痛患者针对Mb的autoAB为93%。针对Mb的autoAB的生理作用仍不清楚。同时测定Mb和针对Mb的autoAB可能有助于稳定型和不稳定型心绞痛的鉴别诊断。
