Dean Madeleine, Weston Adam R W, Osborn David P, Willis Suzie, Patterson Sue, Killaspy Helen, Leurent Baptiste, Crawford Mike J
Centre for Mental Health, Imperial College London , London, UK .
J Ment Health. 2014 Aug;23(4):171-5. doi: 10.3109/09638237.2014.889285. Epub 2014 Mar 24.
UK guidelines recommend that patients with schizophrenia are offered access to social activities, however, the impact of such interventions have not been examined in a large randomized trial.
To investigate the effect of an activity group intervention on mental health and global functioning 12 months after randomization compared to standard care alone.
Secondary analysis of data from the MATISSE study. Primary outcomes were global functioning, assessed using the Global Assessment of Functioning (GAF), and mental health symptoms measured using the Positive and Negative Syndrome Scale (PANSS).
About 140 participants were randomized to activity groups and 137 to standard care alone. Follow-up data were collected from 242 (87%) participants. Mental health improved significantly among those offered activity groups (change in PANSS score = -6.0, 95% CI -2.3 to -9.8) but global functioning did not (change in GAF score = 0.8, 95% CI -1.7 to 3.3). No significant differences were found between treatment arms.
Offering activity groups to patients with schizophrenia was not associated with any additional clinical benefits. There was poor uptake and attendance at activity groups. Interventions that aim to improve negative symptoms may be useful in enabling engagement in psychosocial interventions.
英国指南建议为精神分裂症患者提供参与社交活动的机会,然而,此类干预措施的影响尚未在大型随机试验中得到检验。
与单纯标准护理相比,研究随机分组12个月后活动组干预对心理健康和整体功能的影响。
对MATISSE研究的数据进行二次分析。主要结局是使用功能大体评定量表(GAF)评估的整体功能,以及使用阳性和阴性症状量表(PANSS)测量的心理健康症状。
约140名参与者被随机分配至活动组,137名参与者被随机分配至单纯标准护理组。从242名(87%)参与者处收集了随访数据。接受活动组干预的参与者心理健康状况显著改善(PANSS评分变化=-6.0,95%可信区间-2.3至-9.8),但整体功能未改善(GAF评分变化=0.8,95%可信区间-1.7至3.3)。各治疗组之间未发现显著差异。
为精神分裂症患者提供活动组干预未带来任何额外的临床益处。活动组的参与率和出勤率较低。旨在改善阴性症状的干预措施可能有助于促进对心理社会干预的参与。