Luk Elena, Sneyers Barbara, Rose Louise, Perreault Marc M, Williamson David R, Mehta Sangeeta, Cook Deborah J, Lapinsky Stephanie C, Burry Lisa
Crit Care. 2014 Mar 24;18(2):R46. doi: 10.1186/cc13789.
Physical restraint (PR) use in the intensive care unit (ICU) has been associated with higher rates of self-extubation and prolonged ICU length of stay. Our objectives were to describe patterns and predictors of PR use.
We conducted a secondary analysis of a prospective observational study of analgosedation, antipsychotic, neuromuscular blocker, and PR practices in 51 Canadian ICUs. Data were collected prospectively for all mechanically ventilated adults admitted during a two-week period. We tested for patient, treatment, and hospital characteristics that were associated with PR use and number of days of use, using logistic and Poisson regression respectively.
PR was used on 374 out of 711 (53%) patients, for a mean number of 4.1 (standard deviation (SD) 4.0) days. Treatment characteristics associated with PR were higher daily benzodiazepine dose (odds ratio (OR) 1.05, 95% confidence interval (CI) 1.00 to 1.11), higher daily opioid dose (OR 1.04, 95% CI 1.01 to 1.06), antipsychotic drugs (OR 3.09, 95% CI 1.74 to 5.48), agitation (Sedation-Agitation Scale (SAS) >4) (OR 3.73, 95% CI 1.50 to 9.29), and sedation administration method (continuous and bolus versus bolus only) (OR 3.09, 95% CI 1.74 to 5.48). Hospital characteristics associated with PR indicated patients were less likely to be restrained in ICUs from university-affiliated hospitals (OR 0.32, 95% CI 0.17 to 0.61). Mainly treatment characteristics were associated with more days of PR, including: higher daily benzodiazepine dose (incidence rate ratio (IRR) 1.07, 95% CI 1.01 to 1.13), daily sedation interruption (IRR 3.44, 95% CI 1.48 to 8.10), antipsychotic drugs (IRR 15.67, 95% CI 6.62 to 37.12), SAS <3 (IRR 2.62, 95% CI 1.08 to 6.35), and any adverse event including accidental device removal (IRR 8.27, 95% CI 2.07 to 33.08). Patient characteristics (age, gender, Acute Physiology and Chronic Health Evaluation II score, admission category, prior substance abuse, prior psychotropic medication, pre-existing psychiatric condition or dementia) were not associated with PR use or number of days used.
PR was used in half of the patients in these 51 ICUs. Treatment characteristics predominantly predicted PR use, as opposed to patient or hospital/ICU characteristics. Use of sedative, analgesic, and antipsychotic drugs, agitation, heavy sedation, and occurrence of an adverse event predicted PR use or number of days used.
在重症监护病房(ICU)使用身体约束(PR)与较高的自行拔管率和较长的ICU住院时间相关。我们的目标是描述PR使用的模式和预测因素。
我们对加拿大51个ICU中关于镇痛镇静、抗精神病药物、神经肌肉阻滞剂和PR使用情况的前瞻性观察性研究进行了二次分析。前瞻性收集了所有在两周内入院的接受机械通气的成年患者的数据。我们分别使用逻辑回归和泊松回归,测试了与PR使用及使用天数相关的患者、治疗和医院特征。
711名患者中有374名(53%)使用了PR,平均使用天数为4.1天(标准差(SD)4.0)。与PR相关的治疗特征包括:每日苯二氮䓬类药物剂量较高(比值比(OR)1.05,95%置信区间(CI)1.00至1.11)、每日阿片类药物剂量较高(OR 1.04,95%CI 1.01至1.06)、抗精神病药物(OR 3.09,95%CI 1.74至5.48)、躁动(镇静-躁动评分(SAS)>4)(OR 3.73,95%CI 1.50至9.29)以及镇静给药方式(持续和推注与仅推注)(OR 3.09,95%CI 1.74至5.48)。与PR相关的医院特征表明,大学附属医院ICU的患者接受约束的可能性较小(OR 0.32,95%CI 0.17至0.61)。主要是治疗特征与PR使用天数较多相关,包括:每日苯二氮䓬类药物剂量较高(发病率比(IRR)1.07,95%CI 1.01至1.13)、每日镇静中断(IRR 3.44,95%CI 1.48至8.10)、抗精神病药物(IRR 15.67,95%CI 6.62至37.12)、SAS<3(IRR 2.62,95%CI 1.08至6.35)以及任何不良事件,包括意外设备移除(IRR 8.27,95%CI 2.07至33.08)。患者特征(年龄、性别、急性生理与慢性健康状况评估II评分、入院类别、既往药物滥用、既往精神药物使用、既往精神疾病或痴呆)与PR使用或使用天数无关。
在这51个ICU中,一半的患者使用了PR。与患者或医院/ICU特征不同,主要是治疗特征可预测PR的使用。镇静、镇痛和抗精神病药物的使用、躁动、深度镇静以及不良事件的发生可预测PR的使用或使用天数。