Lu Jian-rao, Yi Yang, Tian Jun, Xiong Chong-xiang, Wang Xin-Hua, Hu Jing, Chen Xiu-feng
Department of Nephrology, The 7th People's Hospital, Shanghai, China.
Blood Purif. 2014;37(2):119-24. doi: 10.1159/000357969. Epub 2014 Mar 20.
The goal of this study was to investigate underlying factors of parathyroid dysfunction in elderly patients undergoing maintenance hemodialysis.
A total of 286 patients on maintenance hemodialysis were included. Hemoglobin, serum creatinine (Scr), blood urea nitrogen (BUN), serum calcium, serum phosphorus (P), intact parathyroid hormone (iPTH), and serum albumin (Alb) were measured and analyzed both before and after dialysis.
A higher incidence of low iPTH level (<150 pg/l) was observed in the elderly group than that in the non-elderly group (55.8 vs. 36.7%, p < 0.05). Elderly patients had a shorter dialysis duration, lighter dry weight, lower concentrations of BUN, Scr, P, iPTH, Alb and standard protein nitrogen present rate (nPNA) compared to that of non-elderly group patients (p < 0.05).
Low iPTH level occurs more frequently in elderly hemodialysis patients. Furthermore, age, serum P, serum Alb and nPNA were independently associated with a low iPTH level.
本研究的目的是调查维持性血液透析老年患者甲状旁腺功能障碍的潜在因素。
共纳入286例维持性血液透析患者。在透析前后测量并分析血红蛋白、血清肌酐（Scr）、血尿素氮（BUN）、血清钙、血清磷（P）、全段甲状旁腺激素（iPTH）和血清白蛋白（Alb）。
老年组低iPTH水平（<150 pg/l）的发生率高于非老年组（55.8%对36.7%，p<0.05）。与非老年组患者相比，老年患者的透析时间更短、干体重更轻、BUN、Scr、P、iPTH、Alb浓度和标准蛋白氮呈现率（nPNA）更低（p<0.05）。
低iPTH水平在老年血液透析患者中更频繁出现。此外，年龄、血清P、血清Alb和nPNA与低iPTH水平独立相关。
