石棉水泥工人停止接触后肺量计测量结果的持续变化。

Continued spirometry changes after cessation of exposure in asbestos-cement workers.

作者信息

Swiątkowska Beata, Sobala Wojciech, Szubert Zuzanna, Szeszenia-Dąbrowska Neonila

机构信息

From the Department of Occupational and Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.

出版信息

J Occup Environ Med. 2014 Apr;56(4):403-8. doi: 10.1097/JOM.0000000000000117.

DOI:10.1097/JOM.0000000000000117

PMID:24662950

Abstract

OBJECTIVE

To assess further progression of spirometry parameters among former asbestos-cement plant workers.

METHODS

The following parameters were assessed: forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the ratio (FEV1/FVC) using a linear regression model with mixed effects.

RESULTS

The analysis included 3005 individuals. Spirometrically defined restrictive ventilatory defects were registered in 21.6% of the patients, obstructive defects in 8.3%, whereas mixed changes in 7%. Current smokers had significantly lower levels of FEV1, FVC, and FEV1/FVC and a steeper decline compared with nonsmokers. More rapid progression was also observed along with increasing termination of exposure. Having higher exposure was associated with a slower decline in FEV1 and FEV1/FVC ratios.

CONCLUSIONS

This report indicates that asbestos-cement workers with higher cumulative exposure still had lower mean levels of spirometric parameters, despite cessation of asbestos exposure many years ago.

摘要

目的

评估曾在石棉水泥工厂工作的工人肺功能测定参数的进一步变化情况。

方法

评估以下参数：使用具有混合效应的线性回归模型，测定1秒用力呼气容积（FEV1）、用力肺活量（FVC）以及两者的比值（FEV1/FVC）。

结果

分析纳入3005名个体。肺功能测定显示，21.6%的患者存在限制性通气功能障碍，8.3%存在阻塞性通气功能障碍，7%存在混合性通气功能障碍。与不吸烟者相比，当前吸烟者的FEV1、FVC和FEV1/FVC水平显著更低，且下降更为明显。随着暴露终止时间的延长，肺功能下降速度更快。暴露水平越高，FEV1和FEV1/FVC比值的下降速度越慢。