Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, USA,
Adv Exp Med Biol. 2014;801:237-50. doi: 10.1007/978-1-4614-3209-8_31.
The ubiquitin-proteasome pathway (UPP) plays an important role in regulating gene expression. Retinal pigment epithelial cells (RPE) are a major source of ocular inflammatory cytokines. In this work we determined the relationship between impairment of the UPP and expression of inflammation-related factors. The UPP could be impaired by oxidative stress or chemical inhibition. Impairment of the UPP in RPE increased the expression of several inflammatory cytokines, such as IL-6 and IL-8. However, the expression of monocyte chemoattractant protein-1 (MCP-1) and complement factor H (CFH) and was reduced upon impairment of the UPP. These data suggest that impairment of the UPP in RPE may be one of the causes of retinal inflammation and abnormal functions of monocyte and the complement system during the pathogenesis of age-related macular degeneration.
泛素-蛋白酶体途径（UPP）在调节基因表达中起着重要作用。视网膜色素上皮细胞（RPE）是眼部炎症细胞因子的主要来源。在这项工作中，我们确定了 UPP 损伤与炎症相关因子表达之间的关系。UPP 可被氧化应激或化学抑制损伤。RPE 中 UPP 的损伤增加了几种炎症细胞因子的表达，如 IL-6 和 IL-8。然而，单核细胞趋化蛋白-1（MCP-1）和补体因子 H（CFH）的表达在 UPP 损伤时减少。这些数据表明，RPE 中 UPP 的损伤可能是年龄相关性黄斑变性发病过程中视网膜炎症以及单核细胞和补体系统异常功能的原因之一。
