Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland,
Adv Exp Med Biol. 2014;801:389-94. doi: 10.1007/978-1-4614-3209-8_49.
Degeneration of cells in the retina is a hallmark of various inherited and acquired blinding diseases in humans. One of the most challenging problems to establish successful treatments for these diseases is to understand the molecular mechanisms that result in retinal degeneration and to identify endogenous rescue pathways which support cell survival. In many mouse models for retinal degeneration, expression of LIF in glial cells in response to a disease condition is crucial for the activation of an elaborate protective system. This mini review will summarize the findings that are related to LIF signaling and discuss the neuroprotective effects of LIF in different animal models.
视网膜细胞的变性是人类各种遗传性和获得性致盲疾病的一个标志。为这些疾病建立成功治疗方法的最具挑战性的问题之一是了解导致视网膜变性的分子机制，并确定支持细胞存活的内源性挽救途径。在许多视网膜变性的小鼠模型中，胶质细胞中 LIF 的表达对疾病条件下的精细保护系统的激活至关重要。这篇迷你综述将总结与 LIF 信号相关的发现，并讨论 LIF 在不同动物模型中的神经保护作用。
