呼吸道上皮腺样腺瘤样错构瘤的临床病理及 EBV 分析。
Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma.
机构信息
Department of Pathology, Nanfang Hospital, Southern Medical University, 510515 Tonghe, Guangzhou, People's Republic of China.
出版信息
Diagn Pathol. 2014 Mar 25;9:70. doi: 10.1186/1746-1596-9-70.
BACKGROUND
To investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV).
METHODS
Clinicopathological data of 53 cases of REAH were retrospectively analyzed. The immunoreactivity for CK 7, CK20, CEA, p53, and Ki-67, Alcian blue-periodic acid-Schiff (AB-PAS) staining and in situ hybridization for EBV-encoded RNA (EBER) were carried out.
RESULTS
REAH lesions were covered with ciliated columnar epithelium and proliferation of subepithelial glands, which were positive for CK7, and negative for CK20, CEA, and p53. Goblet cell metaplasia was stained blue by AB-PAS. The frequency of EBER positive cases in REAH located in nasopharynx was 27.78%, compared with that in the nasal cavity (15.79%) and paranasal sinuses (12.50%), there were no statistical differences.
CONCLUSIONS
REAH is an uncommon entity with distinctive morphologic features and EBV may have nothing to do with REAH.
VIRTUAL SLIDES
The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/5875687401178748.
背景
为了研究中国南方居民呼吸上皮腺样错构瘤（REAH）的临床病理特征，并探讨 REAH 与 Epstein-Barr 病毒（EBV）的相关性。
方法
回顾性分析 53 例 REAH 的临床病理资料，行 CK7、CK20、CEA、p53、Ki-67 免疫组化染色、Alcian 蓝-过碘酸雪夫（AB-PAS）染色及 EBV-编码 RNA（EBER）原位杂交检测。
结果
REAH 病变被覆纤毛柱状上皮，上皮下腺体增生，CK7 阳性，CK20、CEA、p53 阴性，AB-PAS 染色见杯状细胞化生呈蓝色。EBER 阳性病例在鼻咽部 REAH 中的检出率为 27.78%，与鼻腔（15.79%）和鼻窦（12.50%）相比，差异无统计学意义。
结论
REAH 是一种形态特征独特的少见病变，与 EBV 无关。
虚拟幻灯片
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