Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.
Cancer Control. 2014 Apr;21(2):114-23. doi: 10.1177/107327481402100203.
Primary tumors are rare and those localized to a single location offer the potential for cure. To achieve this, early recognition of the primary tumor and proper workup and treatment are essential.
The authors reviewed the literature and best practices to provide recommendations on primary spine tumor treatment. Appropriate workup of primary spine tumors and treatment algorithms are also discussed.
Patients suspected of a primary spine tumor should undergo fine-needle aspirate biopsy following consultation with the surgical team to ensure the biopsy tract is surgically resectable should the need arise. Once pathology is confirmed, metastatic workup should be performed to guide the level of treatment. If a localized lesion with poor radiation and chemotherapeutic response is diagnosed, then en bloc resection may be required for cure. If en bloc resection is not feasible or metastatic lesions are present, then radiation and medical oncology specialists must work in conjunction with the surgical team to determine the best treatment options.
Patients with suspected primary tumors of the spine should be treated in a multidisciplinary fashion from the outset. With thoughtful management, these lesions offer the opportunity for surgical cure.
原发性肿瘤较为罕见,且局限于单一部位的肿瘤有治愈的可能。要实现这一目标,早期识别原发性肿瘤并进行适当的检查和治疗至关重要。
作者回顾了文献和最佳实践,为原发性脊柱肿瘤的治疗提供了建议。还讨论了原发性脊柱肿瘤的适当检查和治疗方案。
怀疑患有原发性脊柱肿瘤的患者应在与手术团队协商后进行细针抽吸活检,以确保在需要时可通过手术切除活检通道。一旦病理得到证实,应进行转移灶检查以指导治疗水平。如果诊断为对放疗和化疗反应不佳的局限性病变,则可能需要整块切除以达到治愈效果。如果整块切除不可行或存在转移病灶,则放射肿瘤学和医学肿瘤学专家必须与手术团队合作,以确定最佳治疗方案。
应从一开始就对疑似脊柱原发性肿瘤的患者进行多学科治疗。通过精心管理,这些病变有机会通过手术治愈。