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流感特异性细胞毒性T细胞识别受到序列和MHC限制均不相关的肽的抑制。

Influenza-specific cytotoxic T-cell recognition is inhibited by peptides unrelated in both sequence and MHC restriction.

作者信息

Bodmer H C, Bastin J M, Askonas B A, Townsend A R

机构信息

Institute for Medical Research, Mill Hill, London.

出版信息

Immunology. 1989 Feb;66(2):163-9.

PMID:2466767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385081/
Abstract

Two related peptides from the nucleoprotein (NP) sequence 365-380, derived from influenza virus isolates A/PR/8/34 and A/NT/60/68, are recognized by mutually exclusive sets of Db (Class I)-restricted cytotoxic T-lymphocyte (CTL) clones. These peptides compete with each other for presentation on Db-bearing target cells in vitro. A Kk-restricted nucleoprotein epitope (NP 50-63), which is unrelated in sequence, competes more efficiently on H-2b target cells but is not itself recognized by virus-specific CTL from influenza-infected H-2b mice. A peptide sequence from the class I molecules Cw3 and Db can also compete, but additional unrelated peptides do not do so at equimolar concentrations. Our results show that competition is at the level of the target cell and imply that the binding specificity of the class I molecule Db is broader than indicated by the immune response phenotype of the C57BL (H-2b) mouse.

摘要

来源于流感病毒分离株A/PR/8/34和A/NT/60/68的核蛋白（NP）序列365 - 380中的两种相关肽段，可被相互排斥的一组Db（I类）限制性细胞毒性T淋巴细胞（CTL）克隆识别。这些肽段在体外针对携带Db的靶细胞呈递时相互竞争。一种序列不相关的Kk限制性核蛋白表位（NP 50 - 63），在H - 2b靶细胞上竞争效率更高，但本身不能被来自感染流感的H - 2b小鼠的病毒特异性CTL识别。来自I类分子Cw3和Db的肽段序列也能竞争，但等摩尔浓度下其他不相关肽段则不能。我们的结果表明竞争发生在靶细胞水平，这意味着I类分子Db的结合特异性比C57BL（H - 2b）小鼠的免疫反应表型所显示的更广泛。