一种用于兔模型中治疗临界尺寸长骨缺损的可注射壳聚糖-脱矿骨基质复合物的特性研究
Characterization of an injectable chitosan-demineralized bone matrix hybrid for healing critical-size long-bone defects in a rabbit model.
作者信息
Shuang F, Hou S-X, Zhao Y-T, Zhong H-B, Xue C, Zhu J-L, Bu G-Y, Cao Z
机构信息
Department of Orthopedics, Institute of Orthopedics, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
出版信息
Eur Rev Med Pharmacol Sci. 2014;18(5):740-52.
BACKGROUND
The effect of injectable demineralized bone matrix (DBM) on bone repair is not known. Here, we tested the hypothesis that injectable DBM can heal a critical-size diaphyseal radius defect in a rabbit model.
MATERIALS AND METHODS
The bone defect was filled with DBM powder, injectable DBM or powdered, freeze-dried powdered allografts. Radiological determination, gross evaluation, histology, and micro-computer tomography was carried out 4, 8, and 12 weeks after the surgery, respectively.
RESULTS
The injectable DBM group yielded better when compared with the freeze-dried powder group (p < 0.05). Moreover, biomechanical functionality was restored comparable to normal levels in the injectable DBM group.
CONCLUSIONS
The injectable DBM was as effective in structurally and functionally repairing bone defects as the DBM powder and more effective than the freeze-dried bone powder. Thus, our study supports the use of injectable DBM for bone healing.
背景
可注射脱矿骨基质（DBM）对骨修复的效果尚不清楚。在此，我们测试了一个假设，即可注射DBM能够在兔模型中治愈临界大小的骨干桡骨缺损。
材料与方法
骨缺损分别用DBM粉末、可注射DBM或粉末状冻干异体骨移植填充。术后4周、8周和12周分别进行放射学测定、大体评估、组织学检查和微型计算机断层扫描。
结果
与冻干粉末组相比，可注射DBM组效果更好（p < 0.05）。此外，可注射DBM组的生物力学功能恢复到与正常水平相当。
结论
可注射DBM在结构和功能上修复骨缺损方面与DBM粉末一样有效，且比冻干骨粉更有效。因此，我们的研究支持使用可注射DBM促进骨愈合。
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