Li Rong, Du Juan, Hou Jian
Hematology. 2015 Jan;20(1):11-7. doi: 10.1179/1607845414Y.0000000163. Epub 2014 Mar 27.
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder. The etiology of MGUS progression remains unclear and is a current topic of investigation.
This review summarizes the essential features of MGUS and the potential risk factors for MGUS of progression.
Many clinical studies have been conducted to identify the critical risk markers that play important roles in progression. Some clinical variables, such as immunophenotypic markers and cytogenetic changes, have been recognized as potential risk factors.
In this review, we discuss novel insights from recent studies of potential risk factors, and we propose future directions for clinical management and additional studies.
意义未明的单克隆丙种球蛋白病（MGUS）是一种癌前浆细胞疾病。MGUS进展的病因仍不清楚，是当前的研究课题。
本综述总结了MGUS的基本特征以及MGUS进展的潜在风险因素。
已经进行了许多临床研究以确定在进展中起重要作用的关键风险标志物。一些临床变量，如免疫表型标志物和细胞遗传学改变，已被认为是潜在的风险因素。
在本综述中，我们讨论了近期关于潜在风险因素研究的新见解，并提出了临床管理和进一步研究的未来方向。
