Xpert（®）MTB/RIF分子检测对肺结核延迟诊断的影响。
Impact of the Xpert(®) MTB/RIF molecular test on the late diagnosis of pulmonary tuberculosis.
作者信息
Ramirez H L Buchelli, García-Clemente M M, Alvarez-Álvarez C, Palacio-Gutierrez J J, Pando-Sandoval A, Gagatek S, Arias-Guillén M, Quezada-Loaiza C A, Casan-Clará P
机构信息
Área de Gestión Clínica del Pulmón, Unidad de Neumología, Hospital Universitario Central de Asturias, Oviedo, Spain.
Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Spain.
出版信息
Int J Tuberc Lung Dis. 2014 Apr;18(4):435-7. doi: 10.5588/ijtld.13.0747.
We analysed the impact of the Xpert(®) MTB/RIF molecular test on health-care diagnostic delay among tuberculosis patients. Diagnostic delay was 17.2 days (standard deviation 23.2, median 10 days). Of 128 patients recruited into the study, 60 (47%) were smear-negative; of these, 40 (67%) were Xpert-positive and were started on treatment without culture. The sensitivity of smear microscopy was 53% compared with 82% for Xpert. In smear-negative patients, delay in Xpert-positive and -negative patients was respectively 15.5 ± 13.2 and 25.5 ± 12.5 days (P = 0.002). We conclude that Xpert results were significantly associated with shorter health-care diagnostic delay, particularly in smear-negative patients.
我们分析了Xpert（®）MTB/RIF分子检测对结核病患者医疗诊断延迟的影响。诊断延迟为17.2天（标准差23.2，中位数10天）。纳入该研究的128例患者中，60例（47%）涂片阴性；其中40例（67%）Xpert检测呈阳性，未进行培养即开始治疗。涂片显微镜检查的敏感性为53%，而Xpert为82%。在涂片阴性患者中，Xpert检测阳性和阴性患者的延迟分别为15.5±13.2天和25.5±12.5天（P = 0.002）。我们得出结论，Xpert检测结果与较短的医疗诊断延迟显著相关，尤其是在涂片阴性患者中。
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