School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Australia.
Chem Soc Rev. 2014 Oct 7;43(19):6701-15. doi: 10.1039/c4cs00026a. Epub 2014 Mar 27.
Alzheimer's disease is the most common form of age-related neurodegenerative dementia. The disease is characterised by the presence of plaques in the cerebral cortex. The major constituent of these plaques is aggregated amyloid-β peptide. This review focuses on the molecular aspects of metal complexes designed to bind to amyloid-β. The development of radioactive metal-based complexes of copper and technetium designed as diagnostic imaging agents to detect amyloid burden in the brain is discussed. Separate sections of the review discuss the use of luminescent metal complexes to act as non-conventional probes of amyloid formation and recent research into the use of metal complexes as inhibitors of amyloid formation and toxicity.
阿尔茨海默病是最常见的与年龄相关的神经退行性痴呆形式。该疾病的特征是大脑皮层中有斑块存在。这些斑块的主要成分是聚集的淀粉样β肽。本综述重点介绍了设计用于与淀粉样β结合的金属配合物的分子方面。讨论了设计为诊断成像剂以检测大脑中淀粉样负担的放射性金属铜和锝配合物的开发。该综述的单独部分讨论了使用发光金属配合物作为淀粉样形成的非常规探针的用途，以及最近关于使用金属配合物作为淀粉样形成和毒性抑制剂的研究。
