Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas - Universidad Pablo de Olavide - Junta de Andalucía, Carretera de Utrera, km1, Seville, 41013, Spain.
Biogerontology. 2014 Jun;15(3):279-88. doi: 10.1007/s10522-014-9497-0. Epub 2014 Mar 27.
Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the NE are a causal effect of normal and premature aging is still controversial. Caenorhabditis elegans is a model organism where observations supporting both, dependent and independent roles of nuclear architecture in the aging process, have been reported. We found that the long-lived glp-1 mutant and dietary restriction delayed age-associated nuclear morphology changes. In addition, we observed that the long-lived mutant of the insulin/IGF receptor daf-2 delayed the age-dependent changes of nuclear architecture at 25 °C, as previously described. However, when daf-2 animals were incubated at 20 °C they remained long-lived, but nuclear appearance changed at similar rate as in the wild type. This supports the idea that both phenotypes, longevity and maintenance of nuclear architecture are tightly associated but can be separated and argues that nuclear morphology deterioration is not a cause of the natural aging process.
核膜（NE）结构与衰老之间存在关联，这一发现源于某些人类早衰疾病是由于核纤层蛋白 A 加工过程中的干扰而导致的，从而导致 NE 形态发生改变。然而，NE 的变化是否是正常和过早衰老的因果效应仍存在争议。秀丽隐杆线虫是一种模式生物，据报道，在该生物中观察到了核结构在衰老过程中具有依赖性和独立性的作用。我们发现，长寿命的 glp-1 突变体和饮食限制延缓了与年龄相关的核形态变化。此外，我们还观察到，胰岛素/IGF 受体 daf-2 的长寿命突变体在 25°C 时延缓了核结构的年龄依赖性变化，如先前所述。然而，当 daf-2 动物在 20°C 下孵育时，它们仍然保持长寿命，但核外观的变化速度与野生型相似。这支持了这样一种观点，即长寿和核结构的维持这两种表型紧密相关，但可以分开，并且表明核形态恶化不是自然衰老过程的原因。
