大鼠摄入无色氨酸氨基酸混合物后，血浆色氨酸、脑色氨酸及血清素的剂量反应性降低。
Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats.
作者信息
Moja E A, Cipolla P, Castoldi D, Tofanetti O
机构信息
Chair of Psychobiology, Medical School, University of Modena, Italy.
出版信息
Life Sci. 1989;44(14):971-6. doi: 10.1016/0024-3205(89)90497-9.
Rats fasted 15 hours were treated p.o. with increasing amounts (660 and 1320 mg/kg body weight) of a mixture containing a fixed proportion of seven essential amino acids (L-phenylalanine 13.6%, L-leucine 6.0%, L-isoleucine 12.1%, L-methionine 12.1%, L-lysine 30.3%, L-threonine 10.6%, L-valine 15.2%) and lacking tryptophan. The mixtures produced a dose-response decrease of free (by 34% after the lower dose and by 58% after the higher dose of the mixture) and total (by 10 and 31%) plasma tryptophan and of brain tryptophan (by 38 and 65%), serotonin (by 17 and 41%) and 5-hydroxyindole acetic acid (by 21 and 49%). The mechanisms of these changes are discussed.
将禁食15小时的大鼠经口给予含七种必需氨基酸（L-苯丙氨酸13.6%、L-亮氨酸6.0%、L-异亮氨酸12.1%、L-蛋氨酸12.1%、L-赖氨酸30.3%、L-苏氨酸10.6%、L-缬氨酸15.2%）固定比例且不含色氨酸的混合物，剂量逐渐增加（660和1320毫克/千克体重）。这些混合物使游离血浆色氨酸（较低剂量混合物后降低34%，较高剂量后降低58%）、总血浆色氨酸（降低10%和31%）、脑色氨酸（降低38%和65%）、5-羟色胺（降低17%和41%）以及5-羟吲哚乙酸（降低21%和49%）产生剂量反应性降低。讨论了这些变化的机制。
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