Moja E A, Stoff D M, Gessa G L, Castoldi D, Assereto R, Tofanetti O
Chair of Psychobiology, Medical School, University of Modena, Italy.
Life Sci. 1988;42(16):1551-6. doi: 10.1016/0024-3205(88)90013-6.
Male healthy subjects, fasting 12 hours, ingested increasing amounts of a mixture containing a fixed proportion of seven essential amino acids (L-isoleucine 11.5%, L-leucine 18.0%, L-lysine 13.1%, L-methionine 18.0%, L-phenylalanine 18.0%, L-threonine 8.2%, L-valine 13.1%) and lacking tryptophan. The diets produced a rapid fall in plasma tryptophan which was proportional to the total amount of the amino acids ingested. Following the highest dose administered (36.6 g) plasma tryptophan fell to a minimum of about 35% the initial level and remained markedly reduced at 6 hours after treatment. The mechanism of this decrease and its potential clinical relevance are discussed.
健康男性受试者禁食12小时后，摄入了越来越多的一种混合物，该混合物含有固定比例的七种必需氨基酸（L-异亮氨酸11.5%、L-亮氨酸18.0%、L-赖氨酸13.1%、L-蛋氨酸18.0%、L-苯丙氨酸18.0%、L-苏氨酸8.2%、L-缬氨酸13.1%）且不含色氨酸。这些饮食导致血浆色氨酸迅速下降，其下降程度与摄入的氨基酸总量成比例。在给予最高剂量（36.6克）后，血浆色氨酸降至初始水平的约35%的最低值，并在治疗后6小时仍显著降低。本文讨论了这种下降的机制及其潜在的临床相关性。
