Wirtz M, Helbig D
Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
Hautarzt. 2014 Apr;65(4):274-6. doi: 10.1007/s00105-014-2784-5.
A 74-year-old male with granulomatous mycosis fungoides presented with multiple, red-brown macules and plaques up to 8 cm in diameter, just as in classical mycosis fungoides. Dermatohistopathologic findings showed extensive granulomatous infiltrates, in which clonality could be detected in various locations via T cell receptor rearrangement. Granulomatous mycosis fungoides is a very rare form of mycosis fungoides with histological resemblance to granulomatous slack skin. It shows a rather aggressive course and can be challenging to diagnose. In our case, combination treatment with bexarotene and bath PUVA, as recommended in guidelines, resulted in an impressive improvement of the skin lesions within ten weeks.
一名74岁的男性患有肉芽肿性蕈样霉菌病，表现为多个直径达8厘米的红棕色斑疹和斑块，与经典蕈样霉菌病相同。皮肤组织病理学检查结果显示广泛的肉芽肿浸润，通过T细胞受体重排在不同部位可检测到克隆性。肉芽肿性蕈样霉菌病是蕈样霉菌病的一种非常罕见的形式，组织学上与肉芽肿性皮肤松弛症相似。它显示出相当侵袭性的病程，诊断可能具有挑战性。在我们的病例中，按照指南推荐，使用贝沙罗汀和浴用补骨脂素联合治疗，在十周内使皮肤病变得到了显著改善。
