一个新的细胞死亡基因在果蝇中发挥作用以修复模式缺陷。
A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.
作者信息
Tanaka Kentaro M, Takahashi Aya, Fuse Naoyuki, Takano-Shimizu-Kouno Toshiyuki
机构信息
Department of Population Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom
Department of Population Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, 192-0397, Japan Research Center for Genomics and Bioinformatics, Tokyo Metropolitan University, Hachioji, 192-0397, Japan.
出版信息
Genetics. 2014 Jun;197(2):739-42. doi: 10.1534/genetics.114.163337. Epub 2014 Mar 25.
Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.
细胞死亡是生物体在发育过程中用于清除多余细胞的一种机制。在此，我们描述了一种新的不依赖于半胱天冬酶的细胞死亡调节因子，即Mabiki（Mabi），它参与了果蝇中由双尾基因额外拷贝导致的头部模式缺陷的修复。Mabiki与依赖于半胱天冬酶的细胞死亡机制共同发挥作用，以在发育过程中提供稳健性。
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