Ma Lili, Lian Jingjing, Zhou Pinghong, Xu Meidong, Yao Liqing, Chen Shiyao
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Mar;17(3):272-4.
To investigate the efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection(ESD) and delayed bleeding.
A total of 9874 patients with gastrointestinal mucosal or submucosal tumors underwent ESD in our center from September 2006 to August 2013 and intractable bleeding occurred during ESD in 5 cases. Under the condition of no effective hemostasis methods, the tissue adhesive injection or spray were used to stop the bleeding. The efficacy and safety were evaluated.
All the 5 cases were successfully managed by the hemostasis method with tissue adhesive without any adverse event. In follow-up of two months after operation, wound healing and scar formation were observed under endoscopy.
Tissue adhesive is safe, effective and fast for intractable bleeding during ESD and delayed bleeding.
探讨组织黏合剂在内镜黏膜下剥离术（ESD）术中难治性出血及迟发性出血的疗效。
2006年9月至2013年8月，本中心共有9874例胃肠道黏膜或黏膜下肿瘤患者接受ESD治疗，其中5例在ESD术中发生难治性出血。在无有效止血方法的情况下，采用注射或喷洒组织黏合剂进行止血，并评估其疗效及安全性。
5例均通过组织黏合剂止血方法成功止血，无任何不良事件发生。术后2个月随访，内镜下观察创面愈合及瘢痕形成情况。
组织黏合剂用于ESD术中难治性出血及迟发性出血安全、有效且迅速。
