Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic ; Psychotherapeutic and Psychosomatic Clinic ESET, Prague, Czech Republic.
Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic ; Central European Institute of Technology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Neuropsychiatr Dis Treat. 2014 Mar 17;10:487-91. doi: 10.2147/NDT.S57627. eCollection 2014.
Dissociation likely plays a key role in schizophrenia and borderline personality disorder (BPD), although empirical studies that compare specific manifestations of these symptoms in schizophrenia and BPD are rare. In this context, the purpose of this study was to compare the occurrence of dissociative and other psychopathological symptoms in these disorders, and to assess the possible influence of antipsychotic medication on the dissociative symptoms.
We assessed 31 patients with schizophrenia and 36 patients with BPD. Dissociative symptoms were measured by the Dissociative Experiences Scale (DES), symptoms related to stress and traumatic experiences were assessed using the Trauma Symptom Checklist-40 (TSC-40), and other psychopathological symptoms were measured with the Health of the Nation Outcome Scales (HoNOS). We also assessed actual daily doses of antipsychotic medication in chlorpromazine equivalents in all participants.
The results show that symptoms of traumatic stress measured by the TSC-40 had significantly higher scores in the BPD group. The data also show that dissociative symptoms (DES) were significantly correlated with symptoms of traumatic stress (TSC-40) and with symptoms assessed by the HoNOS. Remarkably significant correlations were found between levels of antipsychotic medication and the DES and between antipsychotic medication and the depersonalization/derealization component of the DES in BPD patients.
The results support an important role of dissociative processes in schizophrenia and BPD and suggest a significant relationship between manifestations of dissociative symptoms in BPD and antipsychotic medication.
在精神分裂症和边缘型人格障碍（BPD）中，解离可能起着关键作用，尽管比较这些症状在精神分裂症和 BPD 中的具体表现的实证研究很少。在这种情况下，本研究的目的是比较这些疾病中分离性和其他精神病理症状的发生，并评估抗精神病药物对分离性症状的可能影响。
我们评估了 31 名精神分裂症患者和 36 名 BPD 患者。使用分离体验量表（DES）评估分离症状，使用创伤症状清单-40（TSC-40）评估与压力和创伤经历相关的症状，使用国家健康结果量表（HoNOS）评估其他精神病理症状。我们还评估了所有参与者的实际每日抗精神病药物剂量，以氯丙嗪当量表示。
结果表明，TSC-40 测量的创伤应激症状在 BPD 组中得分明显更高。数据还表明，分离症状（DES）与创伤应激症状（TSC-40）和 HoNOS 评估的症状显著相关。在 BPD 患者中，抗精神病药物水平与 DES 以及抗精神病药物与 DES 的人格解体/现实解体成分之间存在显著的相关性。
结果支持分离过程在精神分裂症和 BPD 中的重要作用，并表明 BPD 中分离症状的表现与抗精神病药物之间存在显著关系。
