Caldarella Carmelo, Annunziata Salvatore, Treglia Giorgio, Sadeghi Ramin, Ayati Narjes, Giovanella Luca
Institute of Nuclear Medicine, Department of Radiological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy ; Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Institute of Nuclear Medicine, Department of Radiological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy.
ScientificWorldJournal. 2014 Feb 4;2014:196068. doi: 10.1155/2014/196068. eCollection 2014.
The diagnostic performance of positron emission tomography using (18)F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically review and meta-analyze published data about this topic.
A comprehensive computer literature search of PubMed/MEDLINE, Scopus, and Embase databases was carried out on July 10 to find relevant articles concerning the diagnostic performance of FDG-PET in detecting locoregional nodal involvement in patients with ACC. No language restriction was used. Pooled diagnostic performance on a lesion-based analysis was calculated.
Seven retrospective and five prospective studies have been reviewed. Six studies allowed assessing pooled sensitivity; five studies allowed assessing pooled specificity. Sensitivity and specificity values of FDG-PET/CT on a lesion-based analysis ranged from 31 to 100% and from 53 to 98%, with pooled estimates of 56% (95% CI: 45-67%) and 90% (95% CI: 86-93%), respectively.
Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC. Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan.
多项研究对正电子发射断层扫描使用（18）F - 氟脱氧葡萄糖（FDG - PET）检测肛管癌（ACC）患者淋巴结受累情况的诊断性能进行了调查，但结果相互矛盾。我们研究的目的是系统回顾和荟萃分析关于该主题的已发表数据。
7月10日对PubMed/MEDLINE、Scopus和Embase数据库进行了全面的计算机文献检索，以查找有关FDG - PET检测ACC患者局部区域淋巴结受累诊断性能的相关文章。未设置语言限制。计算基于病变分析的汇总诊断性能。
回顾了7项回顾性研究和5项前瞻性研究。6项研究可评估汇总敏感性；5项研究可评估汇总特异性。基于病变分析的FDG - PET/CT敏感性和特异性值范围分别为31%至100%和53%至98%，汇总估计值分别为56%（95%CI：45 - 67%）和90%（95%CI：86 - 93%）。
我们的荟萃分析表明，FDG - PET是检测ACC患者局部区域淋巴结受累的一种特异性诊断工具。低敏感性是一个主要问题；然而，将FDG - PET与磁共振扫描相结合可获得更高的敏感性。
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