Digestive and Colorectal Surgical Department, Centre of Minimal Invasive Surgery, University of Turin, Molinette Hospital, Turin, Italy.
Br J Cancer. 2013 Feb 19;108(3):527-32. doi: 10.1038/bjc.2012.600. Epub 2013 Jan 17.
Inguinal metastases in patients affected by anal cancer are an independent prognostic factor for local failure and overall mortality. Since 2001, sentinel lymph node biopsy was applied in these patients. This original study reports an update of personal and previous published series, which were compared with Literature to value the incidence of inguinal metastases T-stage related and the overall incidence of false negative inguinal metastases at sentinel node.
In all, 63 patients diagnosed with anal cancer submitted to inguinal sentinel node. Furthermore a research in the Pub Med database was performed to find papers regarding this technique.
In our series, detection rate was 98.4%. Inguinal metastases were evidentiated in 13 patients (20.6%). Our median follow-up was 35 months. In our series, no false negative nodes were observed.
Sentinel node technique in the detection of inguinal metastases in patients affected by anal cancer should be considered as a standard of care. It is indicated for all T stages in order to select patients to be submitted to inguinal radiotherapy, avoiding related morbidity in negative ones. An overall 3.7% rate of false negative must be considered acceptable.
在患有肛门癌的患者中，腹股沟转移是局部失败和总死亡率的独立预后因素。自 2001 年以来，前哨淋巴结活检已应用于这些患者。本研究报告了个人和以前发表的系列的更新，将其与文献进行比较，以评估与 T 分期相关的腹股沟转移的发生率和前哨淋巴结中腹股沟转移的总假阴性率。
共有 63 例诊断为肛门癌的患者接受了腹股沟前哨淋巴结活检。此外，还在 Pub Med 数据库中进行了一项研究，以查找有关该技术的论文。
在我们的系列中，检测率为 98.4%。13 例（20.6%）患者出现腹股沟转移。我们的中位随访时间为 35 个月。在我们的系列中，未观察到假阴性淋巴结。
对于患有肛门癌的患者，前哨淋巴结技术检测腹股沟转移应被视为一种标准的治疗方法。它适用于所有 T 分期，以便选择需要接受腹股沟放疗的患者，避免在阴性患者中出现相关的发病率。总的 3.7%的假阴性率是可以接受的。
