Barba Marta, Cicione Claudia, Bernardini Camilla, Campana Vincenzo, Pagano Ernesto, Michetti Fabrizio, Logroscino Giandomenico, Lattanzi Wanda
Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy.
Departement of Orthopaedics and Traumatology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, Italy.
ScientificWorldJournal. 2014 Jan 28;2014:406159. doi: 10.1155/2014/406159. eCollection 2014.
Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.
骨融合是骨科实践中的一项挑战，尤其适用于脊柱疾病。脊柱融合可定义为通过手术植入具有骨传导性、骨诱导性和成骨性的化合物而实现的两个椎体之间的骨愈合。自体骨移植具备所有这三种特性，被视为金标准。然而，取骨过程会带来较高的发病率。在过去几十年里，人们投入了大量的研究精力来开发成功实现脊柱融合的新方法和技术。近年来，细胞和基因疗法引起了科学界的极大兴趣。对间充质干细胞生物学和成骨分子的深入了解使得它们能够应用于再生医学，这在脊柱手术应用中也是实现骨再生的有吸引力的方法。在这篇综述中，我们旨在描述基于基因和细胞的骨再生方法的发展，这些方法是脊柱融合未来有前景的趋势。
