用于骨组织工程的基因治疗
Gene therapy for bone tissue engineering.
作者信息
Kim Young-Dong, Pofali Prasad, Park Tae-Eun, Singh Bijay, Cho Kihyun, Maharjan Sushila, Dandekar Prajakta, Jain Ratnesh, Choi Yun-Jaie, Arote Rohidas, Cho Chong-Su
机构信息
1Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Korea.
2Department of Chemical Engineering, Institute of Chemical Technology, Mumbai, India.
出版信息
Tissue Eng Regen Med. 2016 Apr 5;13(2):111-125. doi: 10.1007/s13770-016-9063-8. eCollection 2016 Apr.
Abstract
Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
摘要
基因治疗前景广阔，已被广泛研究用于改善骨组织工程中的骨形成和再生疗法。通过结合不同载体（病毒或非病毒）、支架和递送方法，可以递送多种成骨基因。基因增强组织工程方法已成功实现成骨分化和骨形成。在本文中，我们综述了基于基因治疗的骨组织工程的最新进展，讨论了各种策略的优缺点以及基因治疗的总体概况。
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