School of Life Sciences, Jawaharlal Nehru University , New Delhi , India.
Autoimmunity. 2014 Aug;47(5):307-19. doi: 10.3109/08916934.2014.900756. Epub 2014 Mar 27.
Deubiquitination-mediated regulation is important for homeostatic NF-κB activation. Aberrant NF-κB activation associated with various inflammatory and autoimmune disorders is linked with defects in the deubiquitinase A20. A20 is an important anti-inflammatory molecule that is induced by multiple signals and has numerous targets. Polymorphisms within the A20 locus or its altered expression are thought to contribute in development of autoimmune disorders. Further various studies in mice models underscore the biological importance of A20 in prevention of inflammatory conditions. Dysregulated A20 is also been suggested as a link between prolonged inflammation and cancer by preliminary reports. This review summarizes the existing understanding and focuses on the new developments in the field of A20 biology. These developments highlight the importance of A20 in pathophysiology of autoimmune disorders and its scope as therapeutics and a biomarker.
去泛素化介导的调控对于 NF-κB 的稳态激活非常重要。与各种炎症和自身免疫性疾病相关的异常 NF-κB 激活与去泛素酶 A20 的缺陷有关。A20 是一种重要的抗炎分子，它可以被多种信号诱导，并具有多个靶标。A20 基因座内的多态性或其表达改变被认为有助于自身免疫性疾病的发展。进一步的研究表明，在小鼠模型中，A20 在预防炎症状态方面具有重要的生物学意义。初步报告表明，失调的 A20 也是长期炎症和癌症之间的联系。这篇综述总结了现有的认识，并重点介绍了 A20 生物学领域的新进展。这些进展强调了 A20 在自身免疫性疾病的病理生理学中的重要性及其作为治疗剂和生物标志物的范围。
