Song Xiaohong, Tanaka Hideaki, Ohta Kunimasa
Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Dev Growth Differ. 2014 Apr;56(3):199-205. doi: 10.1111/dgd.12121. Epub 2014 Feb 20.
Since the days of Hans Spemann, the ocular lens has served as one of the most important developmental systems for elucidating the fundamental processes of induction and differentiation. Lens is an important source of signals that influence the eye development and a variety of genes expressed by the lens have been identified. The identification of additional molecule(s), especially secreted ones that might mediate signals, will extend our knowledge of the molecular mechanisms of eye and lens development. Here, we will introduce a soluble molecule, Equarin, and discuss its vital role in multiple aspects of lens development.
自汉斯·施佩曼时代起，眼球晶状体就一直是阐明诱导和分化基本过程的最重要发育系统之一。晶状体是影响眼睛发育的重要信号来源，并且已经鉴定出了晶状体表达的多种基因。鉴定出其他分子，尤其是可能介导信号的分泌分子，将扩展我们对眼睛和晶状体发育分子机制的认识。在此，我们将介绍一种可溶性分子Equarin，并讨论其在晶状体发育多个方面的重要作用。
