Firinci Fatih, Soylu Alper, Sarioğlu Sülen, Demir Belde Kasap, Türkmen Mehmet Atilla, Kavukcu Salih
Department of Pediatrics, Dokuz Eylul University School of Medicine , İzmir , Turkey and.
Ren Fail. 2014 Jul;36(6):877-82. doi: 10.3109/0886022X.2014.900386. Epub 2014 Mar 27.
To assess the relationship between mesangial hypercellularity in various childhood nephropathies and clinical and laboratory parameters.
The reports of the renal biopsies were evaluated retrospectively. The patients with diagnosis of IgA nephropathy (isolated and Henoch-Schönlein nephritis), IgM nephropathy, or isolated mesangial proliferative glomerulonephritis were included. Each nephropathy group was divided into two subgroups according to the severity of mesangial hypercellularity as mild and severe. The biochemical data and histopathological findings of the patients were recorded.
When the groups were compared, it was found that the patients with IgA nephropathy had hematuria (p = 0.043) and the patients with IgM nephropathy had nephrotic syndrome more frequently than the other patients (p = 0.01). No difference was detected between the groups regarding the severity of mesangial hypercellularity. On the other hand, when the groups were evaluated within themselves, no significant association was detected between the severity of mesangial hypercellularity and clinical and laboratory parameters. It was determined that the renal biopsy was performed earlier in patients with Henoch-Schönlein nephritis compared to the other cases (p = 0.004). Compared to the isolated IgA nephropathy group, it was found that the number of cases with severe mesangial hypercellularity was higher and the level of proteinuria was more prominent in patients with Henoch-Schönlein nephritis. Additionally, when the patients with Henoch-Schönlein nephritis were evaluated, the degree of proteinuria was found to be higher in patients with severe mesangial hypercellularity compared to those of showing mild mesangial hypercellularity (p = 0.002).
It was observed that there is no direct relation between the severity of mesangial hypercellularity and clinical and laboratory findings in various childhood nephropathies. However, when Henoch-Schönlein nephritis is compared with IgA nephropathy, it was found that the severity of mesangial hypercellularity was higher in cases with Henoch-Schönlein nephritis and the level of proteinuria was more prominent in those cases. However, no difference was detected in glomerular filtration rates and biochemical data with regard to the level of mesangial hypercellularity.
评估儿童期各种肾病中系膜细胞增生与临床及实验室参数之间的关系。
对肾活检报告进行回顾性评估。纳入诊断为IgA肾病（孤立性及过敏性紫癜性肾炎）、IgM肾病或孤立性系膜增生性肾小球肾炎的患者。每个肾病组根据系膜细胞增生严重程度分为轻度和重度两个亚组。记录患者的生化数据和组织病理学结果。
比较各研究组时发现，IgA肾病患者血尿发生率更高（p = 0.043），IgM肾病患者肾病综合征发生率高于其他患者（p = 0.01）。各研究组之间在系膜细胞增生严重程度方面未检测到差异。另一方面，在各研究组内部评估时，未检测到系膜细胞增生严重程度与临床及实验室参数之间存在显著关联。结果表明，与其他病例相比，过敏性紫癜性肾炎患者肾活检时间更早（p = 0.004）。与孤立性IgA肾病组相比，过敏性紫癜性肾炎患者中重度系膜细胞增生病例数更多，蛋白尿水平更显著。此外，在评估过敏性紫癜性肾炎患者时，发现重度系膜细胞增生患者的蛋白尿程度高于轻度系膜细胞增生患者（p = 0.002）。
观察发现，儿童期各种肾病中系膜细胞增生严重程度与临床及实验室检查结果之间无直接关系。然而，将过敏性紫癜性肾炎与IgA肾病进行比较时发现，过敏性紫癜性肾炎病例中系膜细胞增生严重程度更高，蛋白尿水平更显著。但是，在肾小球滤过率和生化数据方面，未检测到系膜细胞增生程度的差异。
