钯催化的烯基卤化物的化学选择性氰化反应。
Chemoselective palladium-catalyzed cyanation of alkenyl halides.
机构信息
School of Chemistry, University of Nottingham , University Park, Nottingham, NG7 2RD, U.K.
出版信息
Org Lett. 2014 Apr 18;16(8):2158-61. doi: 10.1021/ol500618w. Epub 2014 Mar 27.
PMID:24673520
Abstract
A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.
摘要
本文描述了钯催化的烯基卤化物与丙酮氰醇的氰化反应。在优化条件下，一步合成了许多结构多样的含有烯基腈的化合物。该反应具有高效、化学选择性、易于操作以及对多种官能团容忍的优点。
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