细胞毒性反应介质：卵巢癌女性中的颗粒酶A和颗粒酶B

Cytotoxic reaction mediators: granzymes A and B in women with ovarian cancer.

作者信息

Mielczarek-Palacz A, Sikora J, Kondera-Anasz Z, Bednarek I

机构信息

Department of Immunology and Serology, Medical University of Silesia, Katowice, Poland.

出版信息

Tissue Antigens. 2014 Jun;83(6):409-13. doi: 10.1111/tan.12347. Epub 2014 Mar 27.

DOI:10.1111/tan.12347

PMID:24673566

Abstract

The purpose of this work was the assessment of cytotoxic reaction mediators - granzymes A and B in the serum of women with ovarian tumors. The study included 120 women with proven ovarian tumors. The control group consisted of 60 healthy women in whom no pathological changes within the reproductive system were detected. Concentrations of granzymes A and B were measured by enzyme-linked immunosorbent (ELISA) assay. The highest concentrations of the studied parameters were observed in serum of women with ovarian cancer. Moreover, the concentrations of granzymes A and B in patients with ovarian cancer were substantially increased in comparison to concentrations in patients with ovarian cystadenomas (P < 0.0001) or ovarian teratomas (P < 0.0001).

摘要

这项工作的目的是评估患有卵巢肿瘤的女性血清中的细胞毒性反应介质——颗粒酶A和颗粒酶B。该研究纳入了120名经证实患有卵巢肿瘤的女性。对照组由60名健康女性组成，她们的生殖系统未检测到病理变化。采用酶联免疫吸附（ELISA）测定法测量颗粒酶A和颗粒酶B的浓度。在卵巢癌女性的血清中观察到所研究参数的最高浓度。此外，与卵巢囊腺瘤患者（P < 0.0001）或卵巢畸胎瘤患者（P < 0.0001）相比，卵巢癌患者的颗粒酶A和颗粒酶B浓度大幅升高。