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Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells.

作者信息

Diamond S L, Eskin S G, McIntire L V

机构信息

Rice University, Biomedical Engineering Laboratory, Houston, TX 77251.

出版信息

Science. 1989 Mar 17;243(4897):1483-5. doi: 10.1126/science.2467379.

DOI:10.1126/science.2467379
PMID:2467379
Abstract

Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) secretion by cultured human endothelial cells were not affected by exposure to venous shear stress (4 dynes/cm2). However, at arterial shear stresses of 15 and 25 dynes/cm2, the tPA secretion rate was 2.1 and 3.0 times greater, respectively, than the basal tPA secretion rate. PAI-1 secretion was unaffected by shear stress over the entire physiological range.

摘要

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