Purcell Rosemary, Jorm Anthony F, Hickie Ian B, Yung Alison R, Pantelis Christos, Amminger G Paul, Glozier Nick, Killackey Eoin, Phillips Lisa J, Wood Stephen J, Harrigan Susy, Mackinnon Andrew, Scott Elizabeth, Hermens Daniel F, Guastella Adam J, Kenyon Amanda, Mundy Laura, Nichles Alissa, Scaffidi Antoinette, Spiliotacopoulos Daniela, Taylor Lara, Tong Janet P Y, Wiltink Suzanne, Zmicerevska Natalia, McGorry Patrick D
Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.
School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Early Interv Psychiatry. 2015 Dec;9(6):487-97. doi: 10.1111/eip.12133. Epub 2014 Mar 28.
The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problems, in order to longitudinally explore and refine a clinical staging model of the development and progression of mental disorders. This paper presents the baseline demographic and clinical characteristics of the cohort, particularly the nature and severity of psychopathology.
All eligible young people attending one of four headspace clinical services were invited to participate, and completed a battery of self-report and interviewer-administered measures of psychopathology and functional impairment at baseline, which will be repeated at the annual follow up.
Of 1615 eligible clients, 802 young people (66% women; mean age = 18.3 years) consented to participate and completed baseline assessments (participation rate = 50%). The severity of mental health problems varied, with 51% meeting the criteria for probable caseness related to generalized anxiety, 45% presenting with moderate to severe depressive symptoms and over a third experiencing subthreshold psychotic symptomatology. Disordered eating (32%) and problematic tobacco (56%), cannabis (30%) and alcohol (38%) use also affected a significant proportion. Overall, 39% of the cohort were classed as being functionally impaired at baseline.
The Transitions Study recruited a heterogeneous cohort at baseline in relation to the nature and severity of mental health problems and levels of functional impairment. The variation in clinical presentations within the cohort, from mild, through moderate to severe levels of psychopathology and impairment, increases the likelihood of the Transitions Study ultimately being able to achieve its aims of empirically testing a clinical staging model for mental disorders.
“转变研究”旨在建立一个为心理健康问题寻求帮助的年轻人（12 - 25岁）队列，以便纵向探索和完善精神障碍发展与进展的临床分期模型。本文介绍了该队列的基线人口统计学和临床特征，特别是精神病理学的性质和严重程度。
邀请所有在四个headspace临床服务机构之一就诊的符合条件的年轻人参与，并在基线时完成一系列自我报告和由访谈者实施的精神病理学及功能损害测量，这些测量将在年度随访时重复进行。
在1615名符合条件的客户中，802名年轻人（66%为女性；平均年龄 = 18.3岁）同意参与并完成了基线评估（参与率 = 50%）。心理健康问题的严重程度各不相同，51%符合与广泛性焦虑相关的可能病例标准，45%表现出中度至重度抑郁症状，超过三分之一经历阈下精神病性症状。饮食失调（32%）以及有问题的烟草（56%）、大麻（30%）和酒精（38%）使用也影响了相当一部分人。总体而言，39%的队列在基线时被归类为功能受损。
“转变研究”在基线时招募了一个在心理健康问题的性质和严重程度以及功能损害水平方面具有异质性的队列。该队列中临床表现的差异，从轻度到中度再到重度的精神病理学和损害水平，增加了“转变研究”最终能够实现其对精神障碍临床分期模型进行实证检验目标的可能性。
