Barrowcliffe T W, Merton R E, Gray E, Thomas D P
National Institute for Biological Standards and Control, London, UK.
Thromb Haemost. 1988 Dec 22;60(3):434-6.
The effects of four sulphated polysaccharides on bleeding time and lipase release in rabbits have been compared. Unfractionated heparin (UFH) and pentosan polysulphate both gave significant prolongation of bleeding times and high lipase release. Low molecular weight heparin had reduced effects on bleeding time and lipase release, while dermatan sulphate had no influence on either parameter. There was a highly significant correlation (r = 0.97) between these two measurements. These results suggest that the same structural features influence both the haemorrhagic and lipase-releasing properties of sulphated polysaccharides.
比较了四种硫酸化多糖对家兔出血时间和脂肪酶释放的影响。普通肝素（UFH）和戊聚糖多硫酸盐均显著延长出血时间并导致高脂肪酶释放。低分子量肝素对出血时间和脂肪酶释放的影响较小，而硫酸皮肤素对这两个参数均无影响。这两项测量结果之间存在高度显著的相关性（r = 0.97）。这些结果表明，相同的结构特征影响硫酸化多糖的出血和脂肪酶释放特性。
