Fung Samantha J, Fillman Stu G, Webster Maree J, Shannon Weickert Cynthia
Schizophrenia Research Institute, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, Australia; School of Psychiatry, University of New South Wales, Sydney, Australia.
Schizophrenia Research Institute, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, Australia; School of Psychiatry, University of New South Wales, Sydney, Australia.
Schizophr Res. 2014 May;155(1-3):26-30. doi: 10.1016/j.schres.2014.02.021. Epub 2014 Mar 24.
Schizophrenia and bipolar disorder are often viewed as distinct clinical disorders, however there is substantial overlap in their neuropathologies. While compromised cortical interneurons are implicated in both diseases, few studies have examined the relative contribution of the distinct interneuron populations to each psychotic disorder. We report reductions in somatostatin and vasoactive intestinal peptide mRNAs in prefrontal and orbitofrontal cortices in bipolar disorder (n=31) and schizophrenia (n=35) compared to controls (n=34) and increased calbindin mRNA in schizophrenia. We show, at the molecular level, shared deficits in interneuron markers in schizophrenia and bipolar disorder, and a unique interneuron marker increase in schizophrenia.
精神分裂症和双相情感障碍通常被视为不同的临床疾病，然而它们的神经病理学存在大量重叠。虽然受损的皮质中间神经元与这两种疾病都有关联，但很少有研究考察不同中间神经元群体对每种精神障碍的相对贡献。我们报告，与对照组（n = 34）相比，双相情感障碍（n = 31）和精神分裂症（n = 35）患者前额叶和眶额皮质中生长抑素和血管活性肠肽mRNA水平降低，而精神分裂症患者中钙结合蛋白mRNA水平升高。我们在分子水平上表明，精神分裂症和双相情感障碍在中间神经元标志物方面存在共同缺陷，且精神分裂症中有独特的中间神经元标志物增加。
