Brierley Rachel C M, Pike Katie, Miles Alice, Wordsworth Sarah, Stokes Elizabeth A, Mumford Andrew D, Cohen Alan, Angelini Gianni D, Murphy Gavin J, Rogers Chris A, Reeves Barnaby C
Clinical Trials and Evaluation Unit, School of Clinical Sciences, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Old Road, Headington, Oxford OX3 7LF, UK.
Transfus Apher Sci. 2014 Jun;50(3):451-61. doi: 10.1016/j.transci.2014.02.020. Epub 2014 Mar 12.
Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.
心脏手术后红细胞输血的阈值因医院和外科医生而异。TITRe2多中心随机对照试验旨在将来自英国17个中心的2000名患者随机分组，并检验以下假设：与宽松阈值相比，限制性输血阈值将降低术后发病率和医疗服务成本。患者在术前同意参与研究，但只有在术后住院期间血红蛋白降至9 g/dL以下时才会被随机分组。主要结局是随机分组后前三个月内任何严重感染或缺血事件的二元复合结局。在研究的设置和开展过程中遇到了许多挑战。
