免疫原设计以聚焦 B 细胞库。
Immunogen design to focus the B-cell repertoire.
机构信息
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
出版信息
Curr Opin HIV AIDS. 2014 May;9(3):217-23. doi: 10.1097/COH.0000000000000054.
PURPOSE OF REVIEW
This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs).
RECENT FINDINGS
The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens.
SUMMARY
Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.
目的综述
本综述旨在汇集与设计基于 HIV-1 包膜糖蛋白的免疫原以诱导广泛中和抗体 (bNAb) 相关的最新进展。
最近的发现
结构生物学和抗原特异性 B 细胞系的深度测序的结合使用，使人们能够对抗体向广泛而有效的 HIV-1 中和的进化进行横断面和纵向观察。分子建模与蛋白质和糖蛋白工程的最新进展推动了新一代基于病毒包膜糖蛋白 (Env) 的抗原的设计。
总结
尽管证明 HIV-1 bNAb 疫苗诱导的原理仍然缺乏，但许多概念性的障碍正在得到解决。
Zotero 插件