中国老年人群视盘直径及杯盘比的分布及其相关因素
Distribution and associated factors of optic disc diameter and cup-to-disc ratio in an elderly Chinese population.
作者信息
Kuang Tung-Mei, Liu Catherine Jui-Ling, Ko Yu-Chieh, Lee Shui-Mei, Cheng Ching-Yu, Chou Pesus
机构信息
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC.
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
出版信息
J Chin Med Assoc. 2014 Apr;77(4):203-8. doi: 10.1016/j.jcma.2014.01.006. Epub 2014 Mar 25.
BACKGROUND
Glaucoma is the second leading cause of blindness worldwide and East Asian people account for almost half of those affected. Vertical elongation of the optic cup is a characteristic feature of glaucoma. However, there is a significant overlap in the vertical cup-to-disc ratio (VCDR) between normal eyes and eyes affected by glaucoma. The purpose of this study was to determine the distribution of VCDR and vertical disc diameter (VDD) and their predictive factors in a population of elderly Chinese residents in Taiwan.
METHODS
Four hundred and sixty elderly Chinese residents aged 72 years and older in the Shihpai district, Taipei, Taiwan participated in this study. Slit lamp biomicroscopic measurement of the VCDR and VDD after pupil dilation with a 78 diopter lens was performed by one glaucoma specialist. Multiple linear regression analyses were used to fit the best model for independent variables.
RESULTS
The VCDR was recorded for 438 right eyes and 430 left eyes. After excluding participants with glaucoma, the mean ± SD VCDR was 0.44 ± 0.17 for both eyes, and the 97.5(th) percentile was 0.8. A greater VCDR was associated with a longer axial length [VCDR = -0.47 + 0.04(axial length)] under multiple regression analysis. The VDD was obtained for 420 right eyes and 406 left eyes. The mean ± SD VDD for all participants was 1.77 ± 0.22 mm for the right eye and 1.79 ± 0.22 mm for the left eye. A higher body mass index (BMI) and a longer axial length were significantly associated with a larger VDD under multiple regression analysis. [VDD = -0.05 + 0.07 (axial length) + 0.06 (obesity); if BMI <24, then obesity = 0; if BMI ≥ 24, then obesity = 1]. A larger VDD was associated with a larger VCDR (p < 0.001) and the VCDR could be predicted by the equation VCDR = -0.07 + 0.3VDD.
CONCLUSION
A greater VCDR was related to a longer axial length. A greater VDD was related to a higher BMI and a longer axial length.
背景
青光眼是全球第二大致盲原因，东亚人群占青光眼患者的近一半。视杯垂直伸长是青光眼的一个特征性表现。然而，正常眼与青光眼患眼中的垂直杯盘比（VCDR）存在显著重叠。本研究的目的是确定台湾地区老年中国居民人群中VCDR和垂直视盘直径（VDD）的分布及其预测因素。
方法
台湾台北市士林区460名72岁及以上的老年中国居民参与了本研究。由一名青光眼专家使用78屈光度镜片散瞳后，通过裂隙灯生物显微镜测量VCDR和VDD。采用多元线性回归分析来拟合自变量的最佳模型。
结果
记录了438只右眼和430只左眼的VCDR。排除青光眼患者后，双眼的平均±标准差VCDR为0.44±0.17，第97.5百分位数为0.8。在多元回归分析中，更大的VCDR与更长的眼轴长度相关[VCDR = -0.47 + 0.04（眼轴长度）]。获得了420只右眼和406只左眼的VDD。所有参与者右眼的平均±标准差VDD为1.77±0.22mm，左眼为1.79±0.22mm。在多元回归分析中，更高的体重指数（BMI）和更长的眼轴长度与更大的VDD显著相关。[VDD = -0.05 + 0.07（眼轴长度）+ 0.06（肥胖）；如果BMI<24，则肥胖=0；如果BMI≥24，则肥胖=1]）。更大的VDD与更大的VCDR相关（p<0.001），并且VCDR可以通过方程VCDR = -0.07 + 0.3VDD预测。
结论
更大的VCDR与更长眼轴长度相关。更大的VDD与更高的BMI和更长的眼轴长度相关。
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